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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Methoxyamine (Code C78084)

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Terms & Properties

Preferred Name: Methoxyamine

Definition: An orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.

Display Name: Methoxyamine

Label: Methoxyamine

NCI Thesaurus Code: C78084 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0066156  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 67-62-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 599836
PDQ Open Trial Search ID 599836 (check for NCI PDQ open clinical trial info)
UMLS CUI C0066156

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula CH5NO
code C78084
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methoxyamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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