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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Methoxyamine (Code C78084)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Methoxyamine

Definition: An orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.

Display Name: Methoxyamine

Label: Methoxyamine

NCI Thesaurus Code: C78084 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0066156  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Methoxyamine
METHOXYAMINE
TRC102

External Source Codes: 
CAS Registry Number 67-62-9 (see NLM ChemIDplus info)
FDA UNII Code 9TZH4WY30J
PDQ Closed Trial Search ID 599836
PDQ Open Trial Search ID 599836 (check for NCI PDQ open clinical trial info)
UMLS CUI C0066156

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula CH5NO
code C78084
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methoxyamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78084

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