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Version: 17.06d (Release date: 2017-06-26)
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Rivaroxaban (Code C77995)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Rivaroxaban

Definition: An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.

Display Name: Rivaroxaban

Label: Rivaroxaban

NCI Thesaurus Code: C77995 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1739768  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)- 1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
BAY 59-7939
Rivaroxaban
RIVAROXABAN
Xarelto

External Source Codes: 
CAS Registry Number 366789-02-8 (see NLM ChemIDplus info)
FDA UNII Code 9NDF7JZ4M3
PDQ Closed Trial Search ID 701565
PDQ Open Trial Search ID 701565 (check for NCI PDQ open clinical trial info)
UMLS CUI C1739768

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Deep Vein Thrombosis Prophylaxis
Chemical_Formula C19H18ClN3O5S
code C77995
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Rivaroxaban
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77995

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