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Version: 16.11d (Release date: 2016-11-28)
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Immunotherapy Regimen MKC-1106-MT (Code C77971)

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Terms & Properties

Preferred Name: Immunotherapy Regimen MKC-1106-MT

Definition: An immunotherapy regimen containing three components: a plasmid encoding portions of the two melanoma-associated antigens Melan A (also called MART-1) and tyrosinase and two synthetic analogs of Melan-A and tyrosinase antigen epitopes with potential immunostimulating and antitumor activities. First, the plasmid is injected directly into lymph nodes in order to sensitize or prime antigen-presenting cells (APCs) and central memory T cells in lymph nodes to plasmid-expressed Melan A and tyrosinase. After several priming injections with plasmids, the Melan A and tyrosinase synthetic epitope analogs are injected directly into lymph nodes; upon binding to major histocompatibility complex (MHC) molecules on APC cell surfaces, these synthetic epitope analogs may stimulate a "primed" cytotoxic T lymphocyte (CTL) response against melanoma tumor cells, resulting in tumor cell lysis. Melan-A and tyrosinase are overexpressed by melanoma tumor cells.

Display Name: Immunotherapy Regimen MKC-1106-MT

Label: Immunotherapy Regimen MKC-1106-MT

NCI Thesaurus Code: C77971 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL386958  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunotherapy Regimen MKC-1106-MT
MKC-1106-MT

External Source Codes: 
PDQ Closed Trial Search ID 598417
PDQ Open Trial Search ID 598417 (check for NCI PDQ open clinical trial info)
NCI META CUI CL386958

Other Properties:
Name Value (qualifiers indented underneath)
code C77971
Contributing_Source CTRP
Legacy_Concept_Name MKC-1106-MT
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77971

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