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Version: 17.06d (Release date: 2017-06-26)
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FGF Receptor Antagonist HGS1036 (Code C77970)

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Terms & Properties

Preferred Name: FGF Receptor Antagonist HGS1036

Definition: A soluble fusion protein consisting of the extracellular domain of human fibroblast growth factor receptor 1 (FGFR1) fused to the Fc portion of human immunoglobulin G1 (IgG1) with potential antineoplastic and anti-angiogenic activities. FGFR1 receptor antagonist FP-1039 prevents FGFR ligands, such as FGF1, FGF2, FGF4, from binding to their cognate receptors, thereby inhibiting the activation of the related FGFR tyrosine kinases. Inhibition of FGFR1 by this agent may retard tumor cell proliferation and induce tumor cell death. FP-1039 may also inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis. FGFR1 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cellular proliferation, differentiation, angiogenesis, and survival; most ligands that bind to FGFR1 also bind to the related receptors FGFR3 and FGFR4.

Display Name: FGF Receptor Antagonist HGS1036

Label: FGF Receptor Antagonist HGS1036

NCI Thesaurus Code: C77970 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703098  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FGF Receptor Antagonist HGS1036
FP-1039
GSK3052230
HGS1036

External Source Codes: 
PDQ Closed Trial Search ID 599037
PDQ Open Trial Search ID 599037 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703098

Other Properties:
     Name Value (qualifiers indented underneath)
code C77970
Contributing_Source CTRP
Legacy_Concept_Name FGF_Receptor_Antagonist_FP-1039
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77970

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