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Version: 16.11d (Release date: 2016-11-28)
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Aerosol Sargramostim (Code C77915)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Aerosol Sargramostim

Definition: An aerosol inhalation formulation containing a yeast-derived glycosylated recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF) with potential immunostimulating activity. Sargramostim binds to specific cell surface receptors, modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. This agent also activates neutrophils, monocytes, macrophages, and dendritic cells and promotes antigen presentation, upregulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated, lymphokine-activated killer cell function. Aerosol inhalation may help achieve high concentrations of sargramostim in the lung.

Display Name: Aerosol Sargramostim

Label: Aerosol Sargramostim

NCI Thesaurus Code: C77915 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383564  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aerosol GM-CSF
Aerosol Sargramostim

External Source Codes: 
PDQ Closed Trial Search ID 593257
PDQ Open Trial Search ID 593257 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383564

Other Properties:
Name Value (qualifiers indented underneath)
code C77915
Contributing_Source CTRP
Legacy_Concept_Name Aerosol_Sargramostim
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77915

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