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Version: 16.10e (Release date: 2016-10-31)
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Quisinostat (Code C77912)

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Terms & Properties

Preferred Name: Quisinostat

Definition: An orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.

Display Name: Quisinostat

Label: Quisinostat

NCI Thesaurus Code: C77912 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703097  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HDAC Inhibitor JNJ-26481585
JNJ-26481585
Quisinostat
QUISINOSTAT

External Source Codes: 
CAS Registry Number 875320-29-9 (see NLM ChemIDplus info)
FDA UNII Code 9BJ85K1J8S
PDQ Closed Trial Search ID 596704
PDQ Open Trial Search ID 596704 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703097

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C21H26N6O2
code C77912
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name HDAC_Inhibitor_JNJ-26481585
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77912

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