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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 123 Anti-CEA Recombinant Diabody T84.66 (Code C77911)

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Terms & Properties

Preferred Name: Iodine I 123 Anti-CEA Recombinant Diabody T84.66

Definition: A radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal antibody against human carcinoembryonic antigen (CEA) labeled with iodine I 123 (I-123) with potential radioimmunolocalization applications. The antibody moiety of iodine I 123 anti-CEA recombinant diabody T84.66 binds to cells expressing CEA, selectively delivering I-123 upon cellular internalization and allowing the scintigraphic imaging of CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. Compared to whole monoclonal antibodies, diabody fragments offer the advantages of rapid tumor targeting, rapid blood clearance, more uniform tumor distribution, and a lower potential for eliciting an immune response.

Display Name: Iodine I 123 Anti-CEA Recombinant Diabody T84.66

Label: Iodine I 123 Anti-CEA Recombinant Diabody T84.66

NCI Thesaurus Code: C77911 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383557  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Iodine I 123 Anti-CEA Recombinant Diabody T84.66

External Source Codes: 
PDQ Closed Trial Search ID 592881
PDQ Open Trial Search ID 592881 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383557

Other Properties:
     Name Value (qualifiers indented underneath)
code C77911
Contributing_Source CTRP
Legacy_Concept_Name Iodine_I_123_Anti-CEA_Recombinant_Diabody_T84_66
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77911

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