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Version: 17.08d (Release date: 2017-08-28)
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Ad-sig-hMUC-1/ecdCD40L Vaccine (Code C77910)

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Terms & Properties

Preferred Name: Ad-sig-hMUC-1/ecdCD40L Vaccine

Definition: A cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor-associated antigen (TAA) human MUC-1 (hMUC-1) linked to the extracellular domain (ecd) of the co-stimulatory molecule CD40 ligand (CD40L) and an adenovirus signal sequence that encodes a secretory signal peptide (Ad-sig) with potential immunostimulating and antineoplastic activities. Due to the presence of the secretory signal peptide expressed by Ad-sig in the vaccine construct, transfected cells may secrete a fusion protein composed of hMUC-1 and the CD40L ecd. The CD40L moiety part of the fusion protein binds to CD40 receptors on dendritic cells (DCs). Subsequently, DCs may be activated and migrate, T-cells may expand, and a cytotoxic T lymphocyte (CTL) response against tumor cells that overexpress hMUC-1 may follow. MUC-1 is a hypoglycosylated TAA overexpressed by epithelial cancer cells.

Label: Ad-sig-hMUC-1/ecdCD40L Vaccine

NCI Thesaurus Code: C77910 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL386701  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-sig-hMUC-1/ecdCD40L Adenoviral Vector Vaccine
Ad-sig-hMUC-1/ecdCD40L Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 599246
PDQ Open Trial Search ID 599246 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C77910
Legacy_Concept_Name Ad-sig-hMUC-1_ecdCD40L_Vaccine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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