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Version: 17.08d (Release date: 2017-08-28)
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HPV DNA Plasmids Therapeutic Vaccine VGX-3100 (Code C77909)

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Terms & Properties

Preferred Name: HPV DNA Plasmids Therapeutic Vaccine VGX-3100

Definition: A DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating and antineoplastic activities. Administered via intramuscular electroporation, HPV DNA plasmids therapeutic vaccine VGX-3100 expresses E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 proteins, resulting in tumor cell lysis. HPV type 16 and HPV type 18 are the most common HPV types involved in cervical carcinogenesis.

Display Name: HPV DNA Plasmids Therapeutic Vaccine VGX-3100

Label: HPV DNA Plasmids Therapeutic Vaccine VGX-3100

NCI Thesaurus Code: C77909 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703096  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HPV DNA Plasmids Therapeutic Vaccine VGX-3100
VGX-3100

External Source Codes: 
PDQ Closed Trial Search ID 599041
PDQ Open Trial Search ID 599041 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703096

Other Properties:
     Name Value (qualifiers indented underneath)
code C77909
Contributing_Source CTRP
Legacy_Concept_Name HPV_DNA_Plasmids_Therapeutic_Vaccine_VGX-3100
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77909

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