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Version: 16.11d (Release date: 2016-11-28)
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Pevonedistat (Code C77906)

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Terms & Properties

Preferred Name: Pevonedistat

Definition: A small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. Pevonedistat binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Functioning in diverse regulatory activities, proteins conjugated to UBLs like Nedd8 typically are not targeted for proteasomal degradation.

Display Name: Pevonedistat

Label: Pevonedistat

NCI Thesaurus Code: C77906 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703093  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
((1S,2S,4R)-4-(4-((1S)-2,3-Dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl Sulphamate
MLN4924
Nedd8-Activating Enzyme Inhibitor MLN4924
Pevonedistat
PEVONEDISTAT

External Source Codes: 
CAS Registry Number 905579-51-3 (see NLM ChemIDplus info)
FDA UNII Code S3AZD8D215
PDQ Closed Trial Search ID 596795
PDQ Open Trial Search ID 596795 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703093

Other Properties:
Name Value (qualifiers indented underneath)
code C77906
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name NAE_Inhibitor_MLN4924
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77906

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