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Version: 17.06d (Release date: 2017-06-26)
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HLA-A*0201-Restricted URLC10-VEGFR1-VEGFR2 Multipeptide Vaccine (Code C77900)

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Terms & Properties

Preferred Name: HLA-A*0201-Restricted URLC10-VEGFR1-VEGFR2 Multipeptide Vaccine

Definition: A cancer vaccine containing three HLA-A*0201-restricted peptide epitopes with potential immunostimulatory, antiangiogenic, and antitumor activities. Vaccine peptide epitopes are derived from the tumor associated antigen (TAA) URLC (up-regulated in lung cancer 10) and vascular endothelial growth factor receptors (VEGFR) 1 and 2. Upon administration, HLA-A*0201-restricted URLC10-VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against URLC10-expressing tumor cells and the tumor microvasculature expressing VEGFR 1 and 2 peptides; this may result in tumor cell lysis, the inhibition of tumor angiogenesis, and decreased tumor growth. HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide immunogenicity.

Label: HLA-A*0201-Restricted URLC10-VEGFR1-VEGFR2 Multipeptide Vaccine

NCI Thesaurus Code: C77900 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383606  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*0201-Restricted URLC10-VEGFR1-VEGFR2 Multipeptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 596649
PDQ Open Trial Search ID 596649 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383606

Other Properties:
     Name Value (qualifiers indented underneath)
code C77900
Legacy_Concept_Name HLA-A_0201-Restricted_URLC10-VEGFR1-VEGFR2_Multipeptide_Vaccine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77900

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