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Version: 17.06d (Release date: 2017-06-26)
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RARalpha Agonist IRX5183 (Code C77899)

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Terms & Properties

Preferred Name: RARalpha Agonist IRX5183

Definition: An orally bioavailable retinoid acid receptor alpha (RARalpha) agonist and vitamin A derivative, with potential antineoplastic activity. Upon administration, RARalpha agonist IRX5183 binds to and activates RARalpha, which promotes RARalpha-mediated signaling. This results in the transcription of RARalpha-responsive genes, which are responsible for cellular differentiation and proliferation. This results in the induction of cellular differentiation and apoptosis, and leads to the inhibition of cellular proliferation and tumorigenesis. RARalpha is a nuclear receptor and a member of the steroid receptor superfamily; reduced RARalpha signaling is correlated with cancer development in a variety of cancer cell types.

Display Name: RARalpha Agonist IRX5183

Label: RARalpha Agonist IRX5183

NCI Thesaurus Code: C77899 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383603  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AGN-195183
AGN 195183
IRX-5183
IRX5183
IRX 5183
NRX195183
NRX 195183
RARalpha Agonist IRX5183
RARa Agonist IRX5183
VTP-195183
VTP 195183

External Source Codes: 
CAS Registry Number 367273-07-2 (see NLM ChemIDplus info)
FDA UNII Code RC87L028HU
PDQ Closed Trial Search ID 596530
PDQ Open Trial Search ID 596530 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383603

Other Properties:
     Name Value (qualifiers indented underneath)
code C77899
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Retinoid_Analogue_NRX_195183
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77899

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