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Version: 17.12d (Release date: 2017-12-26)
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Technetium Tc 99m-labeled Tilmanocept (Code C77898)

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Terms & Properties

Preferred Name: Technetium Tc 99m-labeled Tilmanocept

Definition: A radiolabeled macromolecule consisting of the chelating agent diethylenetriamine pentaacetic acid (DTPA) and mannose each attached to a dextran backbone and labeled with metastable technetiumTc-99 (Tc-99m), with mannose binding and radioisotopic activities. Upon injection, the mannose moiety of technetium Tc 99m-labeled tilmanocept binds to mannose-binding protein (MBP). As MBPs reside on the surface of dendritic cells and macrophages, this gamma-emitting macromolecule tends to accumulate in lymphatic tissue where it may be imaged using gamma scintigraphy. This agent exhibits rapid clearance from the injection site, rapid uptake and high retention within the first draining lymph node, and low uptake by the remaining lymph nodes. MBP is a C-type lectin that binds mannose or fucose carbohydrate residues, such as those found on the surfaces of many pathiogens, and once bound activates the complement system.

Display Name: Technetium Tc 99m-labeled Tilmanocept

Label: Technetium Tc 99m-labeled Tilmanocept

NCI Thesaurus Code: C77898 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0968236  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
99mTc-Diethylenetriamine Pentaacetic Acid-Mannosyl-Dextran
Technetium Tc 99m-labeled Tilmanocept

External Source Codes: 
PDQ Closed Trial Search ID 596456
PDQ Open Trial Search ID 596456 (check for NCI PDQ open clinical trial info)
UMLS CUI C0968236

Other Properties:
     Name Value (qualifiers indented underneath)
code C77898
Contributing_Source CTRP
Legacy_Concept_Name _99mTc-DTPA-Mannosyl-Dextran
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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