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Version: 17.06d (Release date: 2017-06-26)
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ErbB-2 Inhibitor ARRY-380 (Code C77896)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ErbB-2 Inhibitor ARRY-380

Definition: An orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

Display Name: ErbB-2 Inhibitor ARRY-380

Label: ErbB-2 Inhibitor ARRY-380

NCI Thesaurus Code: C77896 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383576  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARRY-380
ErbB-2 Inhibitor ARRY-380
ONT-380

External Source Codes: 
PDQ Closed Trial Search ID 594366
PDQ Open Trial Search ID 594366 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383576

Other Properties:
     Name Value (qualifiers indented underneath)
code C77896
Contributing_Source CTRP
Legacy_Concept_Name ErbB-2_Inhibitor_ARRY-380
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77896

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