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Version: 17.12d (Release date: 2017-12-26)
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Epothilone KOS-1584 (Code C77892)

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Terms & Properties

Preferred Name: Epothilone KOS-1584

Definition: A second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.

Label: Epothilone KOS-1584

NCI Thesaurus Code: C77892 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1099968  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9,10-Didehydroepothilone D
Epothilone KOS-1584

External Source Codes: 
PDQ Closed Trial Search ID 594152
PDQ Open Trial Search ID 594152 (check for NCI PDQ open clinical trial info)
UMLS CUI C1099968

Other Properties:
     Name Value (qualifiers indented underneath)
code C77892
Legacy_Concept_Name Epothilone_KOS-1584
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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