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Version: 17.06d (Release date: 2017-06-26)
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Sapitinib (Code C77887)

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Terms & Properties

Preferred Name: Sapitinib

Definition: An erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. erbB kinase inhibitor AZD8931 binds to and inhibits erbB tyrosine receptor kinases, which may result in the inhibition of cellular proliferation and angiogenesis in tumors expressing erbB. The erbB protein family, also called the epidermal growth factor receptor (EGFR) family, plays major roles in tumor cell proliferation and tumor vascularization.

Label: Sapitinib

NCI Thesaurus Code: C77887 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703086  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-n-methylacetamide
AZD8931
ErbB Kinase Inhibitor AZD8931
Sapitinib
SAPITINIB

External Source Codes: 
CAS Registry Number 848942-61-0 (see NLM ChemIDplus info)
FDA UNII Code 3499328002
PDQ Closed Trial Search ID 593099
PDQ Open Trial Search ID 593099 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703086

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H25ClFN5O3
code C77887
Contributing_Source FDA
Legacy_Concept_Name ErbB_Kinase_Inhibitor_AZD8931
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77887

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