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Version: 16.11d (Release date: 2016-11-28)
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Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66 (Code C77885)

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Terms & Properties

Preferred Name: Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66

Definition: A radioimmunoconjugate comprised of a chimeric monoclonal antibody against human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y90 DOTA anti-CEA monoclonal antibody cT84.66 binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers.

Display Name: Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66

Label: Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66

NCI Thesaurus Code: C77885 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387153  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
cT84.66
Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66
Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody cT84.66

External Source Codes: 
PDQ Closed Trial Search ID 592860
PDQ Open Trial Search ID 592860 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387153

Other Properties:
Name Value (qualifiers indented underneath)
code C77885
Contributing_Source CTRP
Legacy_Concept_Name Yttrium_Y_90_DOTA_Anti-CEA_Monoclonal_Antibody_cT84_66
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77885

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