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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Lexibulin (Code C77882)

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Terms & Properties

Preferred Name: Lexibulin

Definition: An orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.

Label: Lexibulin

NCI Thesaurus Code: C77882 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703082  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-ethyl-3-(2-methoxy-4-(5-methyl-4-(((1s)-1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea
CYT997
Lexibulin
LEXIBULIN
Tubulin Inhibitor CYT997

External Source Codes: 
CAS Registry Number 917111-44-5 (see NLM ChemIDplus info)
FDA UNII Code 2GTU230HA1
PDQ Closed Trial Search ID 598799
PDQ Open Trial Search ID 598799 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703082

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H30N6O2
code C77882
Contributing_Source FDA
Legacy_Concept_Name Tubulin_Inhibitor_CYT997
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77882

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