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Version: 16.10e (Release date: 2016-10-31)
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Oral Milataxel (Code C77880)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oral Milataxel

Definition: An orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.

Label: Oral Milataxel

NCI Thesaurus Code: C77880 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387339  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oral Milataxel
TL-00139
TL139

External Source Codes: 
PDQ Closed Trial Search ID 597742
PDQ Open Trial Search ID 597742 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387339

Other Properties:
Name Value (qualifiers indented underneath)
code C77880
Legacy_Concept_Name Oral_Milataxel
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77880

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