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Version: 17.06d (Release date: 2017-06-26)
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Glycosylated Recombinant Human Interleukin-7 (Code C77879)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Glycosylated Recombinant Human Interleukin-7

Definition: A glycosylated recombinant protein which is chemically identical to or similar to endogenous human interleukin-7 (IL-7) with hematopoietic and immunopotentiating activities. Naturally produced by bone marrow, thymic stromal, and spleen cells, the cytokine interleukin-7 is a hematopoietic growth factor for progenitor B cells and T cells, stimulating proliferation and differentiation of mature T-cells and natural killer (NK) cells. As with glycosylated endogenous proteins, glycosylation of recombinant proteins may fundamentally affect their biological activity, function, clearance from circulation, and antigenicity; glycosylation of recombinant proteins that are chemically idenitical to or similar to endogenous proteins may render protein structures and biological activities that are more similar to those of glycosylated endogenous proteins.

Display Name: Glycosylated Recombinant Human Interleukin-7

Label: Glycosylated Recombinant Human Interleukin-7

NCI Thesaurus Code: C77879 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387271  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CYT107
Glycosylated Recombinant Human Interleukin-7
Glycosylated rhIL-7

External Source Codes: 
PDQ Closed Trial Search ID 597722
PDQ Open Trial Search ID 597722 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387271

Other Properties:
     Name Value (qualifiers indented underneath)
code C77879
Contributing_Source CTRP
Legacy_Concept_Name Glycosylated_Recombinant_Human_Interleukin-7
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77879

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