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Version: 17.06d (Release date: 2017-06-26)
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HLA-A*2402-Restricted URLC10-KOC1-VEGFR1-VEGFR2 Multipeptide Vaccine (Code C77875)

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Terms & Properties

Preferred Name: HLA-A*2402-Restricted URLC10-KOC1-VEGFR1-VEGFR2 Multipeptide Vaccine

Definition: A cancer vaccine containing four HLA-A*2402-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from URLC10 (up-regulated lung cancer 10 or CO16); KOC1 (IGF II mRNA Binding Protein 3); and vascular endothelial growth factor receptors (VEGFRs) 1 and 2. Upon administration, this multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against URL10-, KOC1-, VEGFR1- and VEGFR2-expressing tumor cells, resulting in tumor cell lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.

Label: HLA-A*2402-Restricted URLC10-KOC1-VEGFR1-VEGFR2 Multipeptide Vaccine

NCI Thesaurus Code: C77875 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387276  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*2402-Restricted URLC10-KOC1-VEGFR1-VEGFR2 Multipeptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 597304
PDQ Open Trial Search ID 597304 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387276

Other Properties:
     Name Value (qualifiers indented underneath)
code C77875
Legacy_Concept_Name HLA-A_2402-Restricted_URLC10-KOC1-VEGFR1-VEGFR2_Multipeptide_Vaccine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77875

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