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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic Multipotent Adult Progenitor Cells (Code C77874)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Allogeneic Multipotent Adult Progenitor Cells

Definition: A biologic product that consists of undifferentiated stem cells, obtained from adult bone marrow or other non-embryonic tissue sources, that are expanded in vitro and deposited in master cell banks for "off-the-shelf" use, with potential hematopoiesis-inducing and immunomodulating activities. Allogeneic multipotent adult progenitor cells (MAPCs) are non-immunogenic due to the lack of major histocompatibility (MHC) molecule expression, and so elicit no immune response upon administration. In vivo, bone marrow-derived adult stem cells are capable of maturing into a broad range of cell types and may help restore the immune system by producing multiple therapeutic molecules in response to inflammation and tissue damage.

Display Name: Allogeneic Multipotent Adult Progenitor Cells

Label: Allogeneic Multipotent Adult Progenitor Cells

NCI Thesaurus Code: C77874 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383616  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic Multipotent Adult Progenitor Cells
MultiStem

External Source Codes: 
PDQ Closed Trial Search ID 597298
PDQ Open Trial Search ID 597298 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383616

Other Properties:
     Name Value (qualifiers indented underneath)
code C77874
Contributing_Source CTRP
Legacy_Concept_Name Allogeneic_Human_Adult_Bone_Marrow-Derived_Progenitor_Cells
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77874

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