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Version: 17.10e (Release date: 2017-10-30)
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HLA-A*2402-Restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 Multipeptide Vaccine (Code C77868)

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Terms & Properties

Preferred Name: HLA-A*2402-Restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 Multipeptide Vaccine

Definition: A cancer vaccine containing five HLA-A*2402-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from IGF II mRNA binding protein 3 (KOC1); TTK protein kinase (TTK); URLC10 (up-regulated lung cancer 10); DEP domain containing 1 (DEPDC1); and M phase phosphoprotein 1 (MPHOSPH1). Upon administration, HLA-A*2404-restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing KOC1, TTK, CO16, DEPDC1 and MPHOSPH1 peptides, resulting in tumor cell lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.

Label: HLA-A*2402-Restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 Multipeptide Vaccine

NCI Thesaurus Code: C77868 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383614  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*2402-Restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 Multipeptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 596765
PDQ Open Trial Search ID 596765 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383614

Other Properties:
     Name Value (qualifiers indented underneath)
code C77868
Legacy_Concept_Name HLA-A_2402-Restricted_KOC1-TTK-CO16-DEPDC1-MPHOSPH1_Multipeptide_Vaccine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77868

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