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Version: 16.10e (Release date: 2016-10-31)
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DM4-Conjugated Anti-Cripto Monoclonal Antibody BIIB015 (Code C77864)

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Terms & Properties

Preferred Name: DM4-Conjugated Anti-Cripto Monoclonal Antibody BIIB015

Definition: A humanized IgG1 monoclonal antibody directed against the cell surface-associated protein Cripto and conjugated to the maytansinoid DM4 with potential antineoplastic activity. The monoclonal antibody moiety of DM4-conjugated anti-Cripto monoclonal antibody BIIB015 binds to the tumor associated antigen (TAA) Cripto; upon internalization, the DM4 moiety binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of Cripto-expressing tumor cells. Constitutively expressed during embryogenesis, Cripto belongs to the EGF-CFC family of growth factor-like molecules and plays a key role in signaling pathways of certain transforming growth factor-beta superfamily members; as a TAA, Cripto is overexpressed in carcinomas such as those of the breast, ovary, stomach, lung, and pancreas while its expression is absent in normal tissues.

Label: DM4-Conjugated Anti-Cripto Monoclonal Antibody BIIB015

NCI Thesaurus Code: C77864 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2713087  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BIIB015
DM4-Conjugated Anti-Cripto Monoclonal Antibody BIIB015

External Source Codes: 
PDQ Closed Trial Search ID 596550
PDQ Open Trial Search ID 596550 (check for NCI PDQ open clinical trial info)
UMLS CUI C2713087

Other Properties:
Name Value (qualifiers indented underneath)
code C77864
Legacy_Concept_Name DM4-Conjugated_Anti-Cripto_Monoclonal_Antibody_BIIB015
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77864

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