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Version: 16.11d (Release date: 2016-11-28)
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Smoothened Antagonist BMS-833923 (Code C77861)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Smoothened Antagonist BMS-833923

Definition: An orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO inhibitor BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.

Display Name: Smoothened Antagonist BMS-833923

Label: Smoothened Antagonist BMS-833923

NCI Thesaurus Code: C77861 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2699316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-833923
Smoothened Antagonist BMS-833923
XL139

External Source Codes: 
PDQ Closed Trial Search ID 596304
PDQ Open Trial Search ID 596304 (check for NCI PDQ open clinical trial info)
UMLS CUI C2699316

Other Properties:
Name Value (qualifiers indented underneath)
code C77861
Contributing_Source CTRP
Legacy_Concept_Name Smoothened_Antagonist_BMS-833923
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77861

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