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Version: 17.12d (Release date: 2017-12-26)
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TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes (Code C77859)

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Terms & Properties

Preferred Name: TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes

Definition: A preparation of transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes (CTL) reactive to Epstein-Barr virus (EBV) latent membrane proteins 1 and 2 (LMP 1 and 2) with potential antineoplastic activity. T lymphocytes are transduced with a retroviral vector expressing the dominant-negative mutant type II TGF-beta receptor, which blocks signaling by all three TGF-beta isoforms. These TGF-beta-resistant T-lymphocytes are exposed ex-vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP; subsequent exposure to LMP1- or LMP2-expressing lymphoblastoid cell lines is used to expand the CTL. Administered to patients with EBV-positive tumors, TGF-beta-resistant LMP-specific CTL target LMP-positive cells, which may result in a specific CTL response, followed by cell lysis and inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T lymphocyte activation and expansion.

Display Name: TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes

Label: TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes

NCI Thesaurus Code: C77859 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387741  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TGF-beta-Resistant LMP-Specific CTLs
TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 595701
PDQ Open Trial Search ID 595701 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C77859
Contributing_Source CTRP
Legacy_Concept_Name TGF-b-Resistant_LMP-Specific_Cytotoxic_T-Lymphocytes
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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