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Version: 16.11d (Release date: 2016-11-28)
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Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307 (Code C77858)

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Terms & Properties

Preferred Name: Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307

Definition: A human monoclonal antibody (B11) directed against the mannose receptor and linked to the beta-subunit of human chorionic gonadotropin (hCG beta) with potential immunostimulating and antineoplastic activities. The monoclonal antibody moiety of human monoclonal antibody B11-hCG beta fusion protein CDX-1307 binds to mannose receptors on antigen presenting cells (APCs), including human dendritic cells (DCs) and macrophages. Upon internalization and processing, APCs present the processed hCG beta antigen on their cell surfaces, which may initiate an antibody-dependent cell-mediated cytotoxicity (ADCC) response against hCG beta-expressing tumor cells. The tumor-associated antigen (TAA) hCG beta is selectively overexpressed by a number of tumors including breast, colorectal, pancreatic, bladder and ovarian tumors; its expression may correlate with the stage of disease.

Display Name: Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307

Label: Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307

NCI Thesaurus Code: C77858 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2713084  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CDX-1307
Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307

External Source Codes: 
PDQ Closed Trial Search ID 593942
PDQ Open Trial Search ID 593942 (check for NCI PDQ open clinical trial info)
UMLS CUI C2713084

Other Properties:
Name Value (qualifiers indented underneath)
code C77858
Contributing_Source CTRP
Legacy_Concept_Name Human_Monoclonal_Antibody_B11-hCG_Beta_Fusion_Protein_CDX-1307
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77858

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