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Version: 17.06d (Release date: 2017-06-26)
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B7-DC Crosslinking Antibody rHIgM12B7 (Code C77857)

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Terms & Properties

Preferred Name: B7-DC Crosslinking Antibody rHIgM12B7

Definition: A recombinant form of the monoclonal IgM antibody M12 isolated from a Waldenstrom macroglobulinaemia patient (rHIgM12) with potential immunomodulating activity. B7-DC cross-linking antibody rHIgM12B7 binds and crosslinks the B7 co-stimulatory family member B7-DC (PD-L2) on dendritic cells (DCs), antigen presenting cells (APCs) that play a crucial role in the human immune response. This results in enhanced activation of DCs; enhanced antigen-presenting activity; and increased production of immunomodulatory cytokines (especially interleukin 12); and may potentiate a specific cytotoxic T lymphocyte (CTL) response against Waldenstrom macroglobulinaemia B cells.

Display Name: B7-DC Crosslinking Antibody rHIgM12B7

Label: B7-DC Crosslinking Antibody rHIgM12B7

NCI Thesaurus Code: C77857 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387186  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B7-DC Crosslinking Antibody rHIgM12B7
rHIgM12B7

External Source Codes: 
PDQ Closed Trial Search ID 593681
PDQ Open Trial Search ID 593681 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387186

Other Properties:
     Name Value (qualifiers indented underneath)
code C77857
Contributing_Source CTRP
Legacy_Concept_Name B7-DC_Crosslinking_Antibody_rHIgM12B7
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77857

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