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Version: 16.10e (Release date: 2016-10-31)
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Enteric-Coated Zoledronic Acid Tablet MER-101 (Code C77855)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Enteric-Coated Zoledronic Acid Tablet MER-101

Definition: An oral tablet formulation containing zoledronic acid combined with a proprietary absorption enhancer for improved zoledronic acid gastrointestinal absorption with anti-bone-resorption activity. The third-generation bisphosphonate zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. The proprietary absorption enhancer is a GRAS (generally-recognized-as-safe) food additive.

Display Name: Enteric-Coated Zoledronic Acid Tablet MER-101

Label: Enteric-Coated Zoledronic Acid Tablet MER-101

NCI Thesaurus Code: C77855 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383558  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Enteric-Coated Zoledronic Acid Tablet MER-101
MER-101
Zoledronic Acid Tablet

External Source Codes: 
PDQ Closed Trial Search ID 592901
PDQ Open Trial Search ID 592901 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383558

Other Properties:
Name Value (qualifiers indented underneath)
code C77855
Contributing_Source CTRP
Legacy_Concept_Name Oral_Zoledronic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77855

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