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Version: 17.06d (Release date: 2017-06-26)
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Solitomab (Code C77854)

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Terms & Properties

Preferred Name: Solitomab

Definition: A recombinant bispecific monoclonal antibody directed against both CD3 and epithelial cell adhesion molecule (EpCAM) with potential immunomodulating and antineoplastic activities. Solitomab attaches to both CD3-expressing T lymphocytes and EpCAM-expressing tumor cells, thereby selectively cross-linking tumor and T lymphocytes; this may result in the recruitment of cytotoxic T lymphocytes (CTL) to T lymphocyte/tumor cell aggregates and the CTL-mediated death of EpCAM-expressing tumor cells. CD3 is an antigen expressed on mature T cells; EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers.

Label: Solitomab

NCI Thesaurus Code: C77854 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383556  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-EpCAM BiTE
MT110
Solitomab
SOLITOMAB

External Source Codes: 
CAS Registry Number 1005198-65-1 (see NLM ChemIDplus info)
FDA UNII Code ZQQ51B5708
PDQ Closed Trial Search ID 592863
PDQ Open Trial Search ID 592863 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383556

Other Properties:
     Name Value (qualifiers indented underneath)
code C77854
Contributing_Source FDA
Legacy_Concept_Name Anti-EpCAM_Anti-CD3_Recombinant_Bispecific_Monoclonal_Antibody_MT110
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77854

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