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Version: 17.06d (Release date: 2017-06-26)
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Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A (Code C77853)

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Terms & Properties

Preferred Name: Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A

Definition: A radioimmunoconjugate consisting of a monoclonal antibody directed against the human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. M5A is a monoclonal antibody that binds to a protein called CEA on the surface of some tumor cells. It is linked to a radioisotope called yttrium Y 90, which may help kill the cancer cells. Yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A is a type of radioimmunoconjugate and a type of radiopharmaceutical.

Display Name: Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A

Label: Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A

NCI Thesaurus Code: C77853 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383554  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
M5A
Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A
yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A

External Source Codes: 
PDQ Closed Trial Search ID 592693
PDQ Open Trial Search ID 592693 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383554

Other Properties:
     Name Value (qualifiers indented underneath)
code C77853
Contributing_Source CTRP
Legacy_Concept_Name Yttrium_Y_90_DOTA_Anti-CEA_Monoclonal_Antibody_M5A
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77853

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