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Version: 17.06d (Release date: 2017-06-26)
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Therapeutic Progesterone (Code C777)

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Terms & Properties

Preferred Name: Therapeutic Progesterone

Definition: A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. (NCI04)

Label: Therapeutic Progesterone

NCI Thesaurus Code: C777 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0591309  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione
Corlutina
Corluvite
Corpus luteum hormone
Cyclogest
Delta4-pregnene-3,20-dione
Gestiron
Gestone
Lipo-Lutin
Luteohormone
Lutocyclin
Lutocylin M
Lutogyl
Lutromone
Progestasert
PROGESTERONE
Progesterone
Progestin
Progestogel
Progestol
Progeston
Prolidon
Proluton
Syngesterone
Therapeutic Progesterone
Utrogestan

External Source Codes: 
CAS Registry Number 57-83-0 (see NLM ChemIDplus info)
FDA UNII Code 4G7DS2Q64Y
ChEBI ID CHEBI:17026 (see ChEBI info)
ChEBI ID CHEBI:59826 (see ChEBI info)
NSC Code 64377 (see NCI DTP info)
NSC Code 9704 (see NCI DTP info)
PDQ Closed Trial Search ID 39059
PDQ Open Trial Search ID 39059 (check for NCI PDQ open clinical trial info)
UMLS CUI C0591309

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Amenorrhea; Functional uterine bleeding; Infertility; Maintenance of pregnancy
Chemical_Formula C21H30O2
code C777
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Progesterone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C777

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