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Version: 17.06d (Release date: 2017-06-26)
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Gadoxetate Disodium (Code C77548)

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Terms & Properties

Preferred Name: Gadoxetate Disodium

Definition: A paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI.

Display Name: Gadoxetate Disodium

Label: Gadoxetate Disodium

NCI Thesaurus Code: C77548 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1714000  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Disodium (N-((2S)-2-(bis(carboxymethyl)amino)-3-(p-ethoxyphenyl)propyl)-N-(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))gadolinate(2-)
Eovist
Gadolinium EOB DTPA
Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid
Gadoxetate Disodium
GADOXETATE DISODIUM
Gadoxetic Acid Disodium
Gd-(S)-EOB-DTPA
Gd-EOB-DTPA
Primovist
ZK 139834

External Source Codes: 
CAS Registry Number 135326-22-6 (see NLM ChemIDplus info)
FDA UNII Code HOY74VZE0M
PDQ Closed Trial Search ID 617182
PDQ Open Trial Search ID 617182 (check for NCI PDQ open clinical trial info)
UMLS CUI C1714000

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H28N3O11.Gd.2Na
code C77548
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gadoxetate_Disodium
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77548

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