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Version: 17.06d (Release date: 2017-06-26)
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Histrelin Acetate (Code C77424)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Histrelin Acetate

Definition: The acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production.

Label: Histrelin Acetate

NCI Thesaurus Code: C77424 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0724597  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Histrelin Acetate
HISTRELIN ACETATE
Supprelin
Vantas

External Source Codes: 
CAS Registry Number 76712-82-8 (see NLM ChemIDplus info)
FDA UNII Code QMG7HLD1ZE
PDQ Closed Trial Search ID 732255
PDQ Open Trial Search ID 732255 (check for NCI PDQ open clinical trial info)
UMLS CUI C0724597

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C66H86N18O12.C2H4O2.H2O
code C77424
Contributing_Source FDA
Legacy_Concept_Name Histrelin_Acetate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77424

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