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Version: 17.12d (Release date: 2017-12-26)
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Histrelin Acetate (Code C77424)

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Terms & Properties

Preferred Name: Histrelin Acetate

Definition: The acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production.

Label: Histrelin Acetate

NCI Thesaurus Code: C77424 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0724597  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Histrelin Acetate

External Source Codes: 
CAS Registry Number 76712-82-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 732255
PDQ Open Trial Search ID 732255 (check for NCI PDQ open clinical trial info)
UMLS CUI C0724597

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C66H86N18O12.C2H4O2.H2O
code C77424
Contributing_Source FDA
Legacy_Concept_Name Histrelin_Acetate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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