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Version: 17.06d (Release date: 2017-06-26)
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Procarbazine Hydrochloride (Code C773)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Procarbazine Hydrochloride

Definition: The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

NCI-GLOSS Definition: A drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Matulane blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.

Display Name: Procarbazine Hydrochloride

Label: Procarbazine Hydrochloride

NCI Thesaurus Code: C773 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0205909  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
Ibenzmethyzine hydrochloride
Matulane
MIH hydrochloride
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride
N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride
Natulan
Natulanar
Natunalar
NCI-C01810
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)
p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI)
PCB
PCB hydrochloride
PCB Hydrochloride
PCZ
Procarbazine Hydrochloride
PROCARBAZINE HYDROCHLORIDE
procarbazine hydrochloride
Ro 4-6467/1
Ro 4 6467/1

External Source Codes: 
CAS Registry Number 366-70-1 (see NLM ChemIDplus info)
FDA UNII Code XH0NPH5ZX8
NSC Code 77213 (see NCI DTP info)
PDQ Closed Trial Search ID 41607
PDQ Open Trial Search ID 41607 (check for NCI PDQ open clinical trial info)
UMLS CUI C0205909

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Brain tumors; Hodgkins diseases; Non-Hodgkins lymphoma
Chemical_Formula C12H19N3O.HCl
code C773
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Procarbazine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C773

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