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Version: 17.06d (Release date: 2017-06-26)
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Linaclotide Acetate (Code C77223)

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Terms & Properties

Preferred Name: Linaclotide Acetate

Definition: The acetate salt form of linaclotide, a synthetic, fourteen amino acid peptide and agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related to the guanylin peptide family, with secretagogue, analgesic and laxative activities. Upon oral administration, linaclotide binds to and activates GC-C receptors located on the luminal surface of the intestinal epithelium. This increases the concentration of intracellular cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). cGMP activates the cystic fibrosis transmembrane conductance regulator (CFTR) and stimulates the secretion of chloride and bicarbonate into the intestinal lumen. This promotes sodium excretion into the lumen and results in increased intestinal fluid secretion. This ultimately accelerates GI transit of intestinal contents, improves bowel movement and relieves constipation. Increased extracellular cGMP levels may also exert an antinociceptive effect, through an as of yet not fully elucidated mechanism, that may involve modulation of nociceptors found on colonic afferent pain fibers. Linaclotide is minimally absorbed from the GI tract.

Display Name: Linaclotide Acetate

Label: Linaclotide Acetate

NCI Thesaurus Code: C77223 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2697923  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1->6),(2->10),(5->13)-tris(disulfide), Monoacetate (salt)
Linaclotide Acetate
LINACLOTIDE ACETATE
MD-1100 Acetate
MM-416775

External Source Codes: 
CAS Registry Number 851199-60-5 (see NLM ChemIDplus info)
FDA UNII Code NSF067KU1M
PDQ Closed Trial Search ID 751985
PDQ Open Trial Search ID 751985 (check for NCI PDQ open clinical trial info)
UMLS CUI C2697923

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
Chemical_Formula C59H79N15O21S6.C2H4O2
code C77223
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Linaclotide_Acetate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77223

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