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Version: 17.06d (Release date: 2017-06-26)
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Bisantrene Hydrochloride (Code C77218)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bisantrene Hydrochloride

Definition: The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.

Label: Bisantrene Hydrochloride

NCI Thesaurus Code: C77218 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0955176  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9,10,Anthracenedicarboxaldehyde Dihydrochloride
9,10-Anthracenedicarboxakdehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] Dihydrochloride
9,10-Anthracenedicarboxaldehyde Bis(2-imidazolin-2-yl)hydrazone Dihydrochloride
Bisantrene Dihydrochloride
BISANTRENE HYDROCHLORIDE
Bisantrene Hydrochloride
CL-216942
CL 216942
Orange Crush
Zantrene

External Source Codes: 
CAS Registry Number 71439-68-4 (see NLM ChemIDplus info)
FDA UNII Code 74GNV897RO
NSC Code 337766 (see NCI DTP info)
PDQ Closed Trial Search ID 39136
PDQ Open Trial Search ID 39136 (check for NCI PDQ open clinical trial info)
UMLS CUI C0955176

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H22N8.2HCl
code C77218
Contributing_Source FDA
Legacy_Concept_Name Bisantrene_Hydrochloride
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C77218

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