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Version: 17.06d (Release date: 2017-06-26)
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Probenecid (Code C772)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Probenecid

Definition: A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

NCI-GLOSS Definition: A drug that is used to treat gout and is used together with some antibiotics to make them work better. It is being studied in the treatment of cancer. It belongs to the family of drugs called antibiotic therapy adjuncts.

Label: Probenecid

NCI Thesaurus Code: C772 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0033209  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benemid
PROB
PROBENECID
Probenecid
probenecid
SK-Probenecid

External Source Codes: 
CAS Registry Number 57-66-9 (see NLM ChemIDplus info)
FDA UNII Code PO572Z7917
NSC Code 18786 (see NCI DTP info)
PDQ Closed Trial Search ID 40223
PDQ Open Trial Search ID 40223 (check for NCI PDQ open clinical trial info)
UMLS CUI C0033209

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H19NO4S
code C772
Contributing_Source FDA
Legacy_Concept_Name Probenecid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C772

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