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Version: 17.06d (Release date: 2017-06-26)
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Prednisolone (Code C769)

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Terms & Properties

Preferred Name: Prednisolone

Definition: A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)

NCI-GLOSS Definition: A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid.

Display Name: Prednisolone

Label: Prednisolone

NCI Thesaurus Code: C769 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0032950  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.delta.1-Hydrocortisone
1,2-Dehydrohydrocortisone
Adnisolone
Aprednislon
Capsoid
Cortalone
Cortisolone
Dacortin H
Decaprednil
Decortin H
Delta(1)Hydrocortisone
Delta-Cortef
Delta-Diona
Delta-F
Delta-Phoricol
Delta- Cortef
Delta1-dehydro-hydrocortisone
Deltacortril
Deltahydrocortisone
Deltasolone
Deltidrosol
Dhasolone
Di-Adreson-F
Dontisolon D
Estilsona
Fisopred
Frisolona
Gupisone
Hostacortin H
Hydeltra
Hydeltrasol
Klismacort
Kuhlprednon
Lenisolone
Lepi-Cortinolo
Linola-H-Fett N
Linola-H N
Longiprednil
Metacortandralone
Meticortelone
Meti Derm
Opredsone
Panafcortelone
Precortisyl
Pred-Clysma
Predeltilone
Predni-Coelin
Predni-Helvacort
Prednicortelone
Prednisolone
prednisolone
PREDNISOLONE
Prednisolonum
Prelone
Prenilone
Sterane

External Source Codes: 
CAS Registry Number 50-24-8 (see NLM ChemIDplus info)
FDA UNII Code 9PHQ9Y1OLM
ChEBI ID CHEBI:8378 (see ChEBI info)
NSC Code 9120 (see NCI DTP info)
PDQ Closed Trial Search ID 43296
PDQ Open Trial Search ID 43296 (check for NCI PDQ open clinical trial info)
UMLS CUI C0032950

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Inflammatory conditions; Allergic conditions; Hematologic conditions; Neoplastic conditions; Autoimmune conditions; Replacement therapy in adrenal insufficiency
Chemical_Formula C21H28O5
code C769
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Prednisolone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C769

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