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Version: 17.06d (Release date: 2017-06-26)
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Lisdexamfetamine Dimesylate (Code C76628)

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Terms & Properties

Preferred Name: Lisdexamfetamine Dimesylate

Definition: The dimesylate form and prodrug of the d-isomer of amphetamine, a non-catecholamine sympathomimetic amine with central nervous system (CNS) stimulating activity. Upon administration, lisdexamphetamine is converted to dextroamphetamine through cleavage of the lysine group. Dextroamphetamine acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from its storage sites in nerve terminals in the CNS, and inhibits their uptake within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria, mental alertness and excitement and appetite suppression. As a CNS stimulant, this agent may increase blood pressure.

Label: Lisdexamfetamine Dimesylate

NCI Thesaurus Code: C76628 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1739826  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Lisdexamfetamine Dimesylate
LISDEXAMFETAMINE DIMESYLATE
Vyvanse

External Source Codes: 
CAS Registry Number 608137-33-3 (see NLM ChemIDplus info)
FDA UNII Code SJT761GEGS
PDQ Closed Trial Search ID 663453
PDQ Open Trial Search ID 663453 (check for NCI PDQ open clinical trial info)
UMLS CUI C1739826

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H25N3O.2CH4O3S
code C76628
Contributing_Source FDA
Legacy_Concept_Name Lisdexamfetamine_Dimesylate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C76628

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