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Version: 17.06d (Release date: 2017-06-26)
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Vardenafil Hydrochloride Trihydrate (Code C76318)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Vardenafil Hydrochloride Trihydrate

Definition: The hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection.

Label: Vardenafil Hydrochloride Trihydrate

NCI Thesaurus Code: C76318 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1960918  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Levitra
Vardenafil Hydrochloride
VARDENAFIL HYDROCHLORIDE TRIHYDRATE
Vardenafil Hydrochloride Trihydrate

External Source Codes: 
CAS Registry Number 330808-88-3 (see NLM ChemIDplus info)
FDA UNII Code 5M8S2CU0TS
PDQ Closed Trial Search ID 670474
PDQ Open Trial Search ID 670474 (check for NCI PDQ open clinical trial info)
UMLS CUI C1960918

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H32N6O4S.ClH.3H2O
code C76318
Contributing_Source FDA
Legacy_Concept_Name Vardenafil_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C76318

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