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Version: 17.06d (Release date: 2017-06-26)
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Corticorelin Acetate (Code C76112)

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Terms & Properties

Preferred Name: Corticorelin Acetate

Definition: The acetate salt form of coticorelin, a synthetic peptide of neurohormone corticotropin-releasing factor (CRF), with potential antitumor and antiangiogenesis activities. Upon administration, corticorelin stimulates adrenocorticotropic hormone (ACTH) secretion from the anterior pituitary gland. In turn, ACTH stimulates cortisol production from the adrenal cortex and is regulated by a negative feedback mechanism. Corticorelin appears to inhibit swelling around brain tumors through reduction in vascular leakage and maintenance of endothelial cell integrity. This agent potentially suppresses vascularization and tumor cell growth through reduction of vascular endothelial growth factor (VEGF) that appears to be via activation of corticotrophin-releasing factor receptor 2 (CRFR2), a G protein-coupled receptor.

NCI-GLOSS Definition: A substance being studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone.

Display Name: Corticorelin Acetate

Label: Corticorelin Acetate

NCI Thesaurus Code: C76112 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1515366  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Corticorelin Acetate
human corticotropin-releasing factor
Human Corticotropin-Releasing Factor

External Source Codes: 
CAS Registry Number 86784-80-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 385686
PDQ Open Trial Search ID 385686 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 19437022 (see PubMed Primary Reference info)
UMLS CUI C1515366

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C208H344N60O63S2.C2H4O2
code C76112
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Corticorelin_Acetate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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