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Version: 17.06d (Release date: 2017-06-26)
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Elesclomol (Code C75291)

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Terms & Properties

Preferred Name: Elesclomol

Definition: A small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway. Normal cells are spared because the increase in the level of oxidative stress induced by this agent is below the threshold at which apoptosis is induced.

Display Name: Elesclomol

Label: Elesclomol

NCI Thesaurus Code: C75291 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2608060  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-N'-benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl- oxopropanehydrazidide
Elesclomol
ELESCLOMOL
Propanedioic Acid, Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]

External Source Codes: 
CAS Registry Number 488832-69-5 (see NLM ChemIDplus info)
FDA UNII Code 6UK191M53P
PDQ Closed Trial Search ID 377539
PDQ Open Trial Search ID 377539 (check for NCI PDQ open clinical trial info)
UMLS CUI C2608060

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H20N4O2S2
code C75291
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Elesclomol
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C75291

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