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Version: 17.06d (Release date: 2017-06-26)
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Acenocoumarol (Code C75152)

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Terms & Properties

Preferred Name: Acenocoumarol

Definition: A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life.

Label: Acenocoumarol

NCI Thesaurus Code: C75152 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0000956  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Acenocoumarol
ACENOCOUMAROL

External Source Codes: 
CAS Registry Number 152-72-7 (see NLM ChemIDplus info)
FDA UNII Code I6WP63U32H
ChEBI ID CHEBI:53766 (see ChEBI info)
UMLS CUI C0000956

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H15NO6
code C75152
Contributing_Source FDA
Legacy_Concept_Name Acenocoumarol
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C75152

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