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Version: 17.06d (Release date: 2017-06-26)
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Piroxicam (Code C751)

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Terms & Properties

Preferred Name: Piroxicam

Definition: A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.

Label: Piroxicam

NCI Thesaurus Code: C751 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0031990  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxide
Feldene
Piroxicam
PIROXICAM
PXM

External Source Codes: 
CAS Registry Number 36322-90-4 (see NLM ChemIDplus info)
FDA UNII Code 13T4O6VMAM
ChEBI ID CHEBI:8249 (see ChEBI info)
NSC Code 666076 (see NCI DTP info)
PDQ Closed Trial Search ID 39761
PDQ Open Trial Search ID 39761 (check for NCI PDQ open clinical trial info)
UMLS CUI C0031990

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H13N3O4S
code C751
Contributing_Source FDA
Legacy_Concept_Name Piroxicam
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C751

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