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Version: 17.06d (Release date: 2017-06-26)
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Piperacillin Sodium (Code C749)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Piperacillin Sodium

Definition: The sodium salt of piperacillin, a broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic with bactericidal activity. Piperacillin binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

Label: Piperacillin Sodium

NCI Thesaurus Code: C749 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700463  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CL 227, 193
PIPERACILLIN SODIUM
Piperacillin Sodium
Pipracil
Sodium (2S,5R,6R)-6-((R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate
T-1220

External Source Codes: 
CAS Registry Number 59703-84-3 (see NLM ChemIDplus info)
FDA UNII Code M98T69Q7HP
ChEBI ID CHEBI:8233 (see ChEBI info)
PDQ Closed Trial Search ID 39555
PDQ Open Trial Search ID 39555 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700463

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H26N5O7S.Na
code C749
Contributing_Source FDA
Legacy_Concept_Name Piperacillin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C749

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