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Version: 17.06d (Release date: 2017-06-26)
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Pilocarpine Hydrochloride (Code C748)

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Terms & Properties

Preferred Name: Pilocarpine Hydrochloride

Definition: The hydrochloride salt of a natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to the eye, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accomodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor.

Display Name: Pilocarpine Hydrochloride

Label: Pilocarpine Hydrochloride

NCI Thesaurus Code: C748 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0770456  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pilocarpine Hydrochloride
PILOCARPINE HYDROCHLORIDE
Salagen

External Source Codes: 
CAS Registry Number 54-71-7 (see NLM ChemIDplus info)
FDA UNII Code 0WW6D218XJ
NSC Code 5746 (see NCI DTP info)
PDQ Closed Trial Search ID 42876
PDQ Open Trial Search ID 42876 (check for NCI PDQ open clinical trial info)
UMLS CUI C0770456

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H16N2O2.HCl
code C748
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pilocarpine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C748

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