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Version: 16.11d (Release date: 2016-11-28)
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Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001 (Code C74595)

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Terms & Properties

Preferred Name: Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001

Definition: A cancer vaccine containing a live-attenuated strain of the bacterium Listeria monocytogenes (Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a non-hemolytic listeriolysin O protein with potential immunostimulatory and antineoplastic activities. Upon vaccination, Listeria expresses the HPV 16 E7 antigen and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV 16 E7. This may result in tumor cell lysis. In addition, the Listeria vector itself may induce a potent immune response. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in the majority of cervical cancer cells.

Display Name: Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001

Label: Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001

NCI Thesaurus Code: C74595 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL384120  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADXS11-001
ADXS11-001 Vaccine
Attenuated Live Listeria Encoding HPV 16 E7 Vaccine
Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001
Attenuated Live Listeria Encoding Human Papilloma Virus 16 E7 Vaccine
Lm-LLO-E7
Lovaxin-C

External Source Codes: 
CAS Registry Number 1587258-09-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 673240
PDQ Open Trial Search ID 673240 (check for NCI PDQ open clinical trial info)
NCI META CUI CL384120

Other Properties:
Name Value (qualifiers indented underneath)
code C74595
Contributing_Source CTRP
Legacy_Concept_Name Attenuated_Live_Listeria_Encoding_HPV_16_E7_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74595

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