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Version: 17.06d (Release date: 2017-06-26)
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Lanreotide Acetate (Code C74584)

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Terms & Properties

Preferred Name: Lanreotide Acetate

Definition: The acetate salt of a synthetic cyclic octapeptide analogue of somatostatin. Lanreotide binds to somatostatin receptors (SSTR), specifically SSTR-2 and also to SSTR-5 with a lesser affinity. However, compare with octreotide, this agent is less potent in inhibiting the release of growth hormone from the pituitary gland. Furthermore, lanreotide has an acute effect on decreasing circulating total and free insulin-like growth factor 1 (IGF-I). This agent is usually given as a prolonged-release microparticle or Autogel formulation for the treatment of acromegaly and to relieve the symptoms of neuroendocrine tumors.

Display Name: Lanreotide Acetate

Label: Lanreotide Acetate

NCI Thesaurus Code: C74584 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771414  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AT-1001
L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide, acetate
Lanreotide Acetate
LANREOTIDE ACETATE
Somatuline Depot

External Source Codes: 
CAS Registry Number 127984-74-1 (see NLM ChemIDplus info)
FDA UNII Code IEU56G3J9C
PDQ Closed Trial Search ID 750171
PDQ Open Trial Search ID 750171 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 9641549 (see PubMed Primary Reference info)
UMLS CUI C0771414

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C54H69N11O10S2.C2H4O2
code C74584
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lanreotide_Acetate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74584

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