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Version: 17.06d (Release date: 2017-06-26)
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Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12 (Code C74093)

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Terms & Properties

Preferred Name: Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12

Definition: A radioimmunoconjugate comprised of the monoclonal antibody AHN-12 conjugated to the radioisotope yttrium 90 with potential radioimmunotherapeutic activity. Yttrium Y 90 monoclonal antibody AHN-12 binds to the tyrosine phosphatase CD45, expressed on the surface of normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, this agent may deliver a cytotoxic dose of beta radiation.

Display Name: Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12

Label: Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12

NCI Thesaurus Code: C74093 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383503  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12
Y 90 AHN-12

External Source Codes: 
PDQ Closed Trial Search ID 587979
PDQ Open Trial Search ID 587979 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383503

Other Properties:
     Name Value (qualifiers indented underneath)
code C74093
Contributing_Source CTRP
Legacy_Concept_Name Yttrium_Y_90_Anti-CD45_Monoclonal_Antibody_AHN-12
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74093

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